in short – avoid it, unless you’re willing to sacrifice money for convenience or speed. Always negotiate the price before embarking.
By bus, when your accommodation in Chania is different from the venue:
bus line 21 (destination Galatas / Kalamaki) leaves ca. every 20 minutes from Chania center, Plateia 1866, beside a nice bakery (see photographs); there’s a bus stop directly in front of Hotel Panorama. You can buy bus tickets for your way back to downtown Chania at the reception desk of Hotel Panorama.
Timetable, for download: Bus “21” Timetable Chania Panorama
By bus, from/to Heraklion Airport HER:
take the town bus (painted blue and white) from the airport (buy tickets at kiosk at bus stop); leave bus after ca. 10 min at the KTEL bus station near the harbor (ask the bus driver to give you a signal);
from the KTEL bus station, buses to Chania go every hour; buy your tickets in the waiting room (you can also buy them on the bus);
For more information, xou can also contact the bus company KTEL.